New feeding strategies such as the use of high moisture corn that has enhanced nutrient digestibility in a liquid feeding system can enhance performance and reduce the outflow of nutrients in manure. This study attempts to examine impacts of fermentation  on starch and phytate degradation in high-moisture corn, find the effects of high-moisture corn in liquid feeding systems on gut structure and function and microbial ecology, examine the production of nutrient utilization of starter pigs fed high-moisture corn in liquid feeding systems, and to determine the effects of added phytase in liquid feeding systems containing high-moisture corn on nutrient digestion and manure composition. Studies were conducted to assess the impact of using bacterial inoculants and enzymes on degradation of starch and phytate-phosphorus and appearance of organic acids and alcohol in high-moisture corn mixed with water in a 1 to 2 ratio. Diet effects on structure, function, and microbiota in the gut as well as nutrient digestibility and nutrient excretion have been assessed. Research findings show that phosphorus availability is higher in stored high-moisture corn than in dry corn, phytase is more effective in liquid feeding that in conventional dry feeding, and that commonly used bacterial inoculants are not effective in enhancing the nutritional value of stored high-moisture corn.