The widespread impact of PCVAD and PRRS results in other diseases sometimes being overlooked in the present day. One of these diseases is coccidian, which has the potential for a long-term impact on growth and performance. There is no longer a treatment available on the market, and benchmarking, control, and treatment should be explored. Post weaning diarrhea can be caused by several pathogens, and one of these is E. coli. A more virulent strain appeared in the 1990s, and although research started on treatment it did not continue. PCVAD weakens the immune system and allows otherwise low-infectious pathogens to infect the host. The increased infection rate by these “sui-cide” pathogens could also partially be due to a genetic defect in the modern hog’s immune system. Swine influenza has also re-emerged after triple reassortments of H3N2 were found in swine herds in 2005, and vaccination or prevention are difficult due to the constantly evolving nature and multiple strains of influenza. One of the main public health concerns is salmonellosis that is commonly found in barns, but other pathogens like E. coli and Campylobacter have also been found. Monitoring of diseases is important to track changes in herd health and herd or public risks.