Porcine Circovirus type 2 (PCV2) causes several diseases. Post-Weaning Multisystemic Wasting Syndrome (PMWS) primarily causes enlarged lymph nodes, wasting, diarrhoea, jaundice, coughing, fever, gastric ulcers, and sudden death. This usually hits piglets at 7 to 15 weeks of age, but good management can lower mortality. Porcine Dermatitis and Nephropathy Syndrome (PDNS) affects the skin and the kidneys. Clinical signs include red/purple lesions that begin on the hindquarters, and severe cases can lead to fever, lameness, anorexia and weight loss. The kidneys are often enlarged, pale, and covered with haemorrhages. PDNS typically affects nursery and grow-finish pigs and is sporadic. Pre-natal Myocarditis and Reproductive Failure is common in start-up herds. It causes abortions, increased stillbirths, increased foetal mummification rates, and cardiac lesions. At the time of publication, there were no licensed PCV2 vaccinations, but 3 were in the works.