The control of Salmonella in swine is vital for the respect of regulations, and to prevent meat contamination and transmission of antibiotics resistant strains to human by meat products. The meaning of this study was Salmonella infections in swine, particularly strains involved in septicemia. An experimental infection in order to determine the dosage causing typical profuse diarrhea and physical exhaustion has been performed. Carcasses of pigs having shown clinical signs of salmonellosis were significantly more often contaminated by Salmonella. Examination of plasmidic profiles revealed that invasive strains had small molecular weight plasmids associated with this invasive power. For many septicemic strains of Salmonella, incubation of those bacteria in albumin significantly reduced the phagocytosis response against them. Despite the generation of thousands of mutant strains of S. typhimurium, it was impossible to produce strains lacking the capacity to produce GAPDH surface proteins. Optimal laboratory conditions has been established for detecting the genes coding for the multi-resistance associated integron (nt), for resistance to flofenicol (flo), for an invasin (inv) and for the detection of the gene (spvC) already associated with virulence. It was demonstrated that multi-resistant strains of S. typhimurium associated with septicemia in swine are also associated with enteritis in human. Using identification of the GAPDH proteins present at the surface of Salmonella bacteria at all stages of infection, the Chaire de recherche en salubrité des viandes developed a serologic test for checking the animal contamination status. A vaccination protocol with microspheres that will allow reaching every tissue for adequate protection must now be developed.