This study investigates the response to infection from porcine reproductive and respiratory syndrome virus (PRRSV) for 2 genetically diverse commercial pig lines. Previous analysis showed significant line differences in susceptibility to PRRSV infection. This study revealed significant line differences in growth during infection. Line B was characterized by faster growth rate than line A in the absence of infection and suffered more severe clinical disease and greater reduction in BW growth after infection. It was concluded that a comprehensive framework describing the interaction between the biological mechanisms and the genetic influence of these would be desirable for achieving progress in the genetic control of this disease.

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