In this study the association between a silent C3469T substitution at exon 3 of the Lep gene with SB thickness and IMF content and fatty acids (FA) composition at different time-points throughout the finishing period was examined withthe aim of understanding if genotype effects are temporally modulated. It was found that the associations
between gene polymorphisms and fatness vary with age and fat tissue. Although this circumstance makes more difficult
the identification of causal mutations, it can help for acting at specific ages or tissues. Thus, the fact that, at late ages, the C3469T Lep polymorphism may be preferentially associated with intramuscular fat content but not to subcutaneous fat can be useful for selecting them independently of each other.

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