This study examined the relationships among stockperson and cow variables of 66 commercial farms. Stockpersons were assessed in terms of their attitudes toward cows and their behaviour while handling animals. The cows were assessed in terms of their response to humans and their productivity. Stockpersons with a positive attitude toward cows were less likely to use forceful, negative, tactile (touching) interactions with the animals. Cows that were handled with fewer such interactions were more willing to approach humans. Animals that were willing to approach humans had higher reproductive performance (conception rate). Also, cows that received a higher number of forceful interactions produced less milk and had higher cortisol levels. The results of this study illustrate the complex relationship among stockperson attitude, handling, cow productivity and welfare. Although causal relationships could not be determined, the area offers considerable potential for research on human-animal relationships that positively affect animal welfare.