The aim of this study was to evaluate the occurrence of staphylococci resistant to various antimicrobial agents in the entire production chain of swine meat commodities, from animal farming to final foods. Resistant staphylococcal isolates were collected and examined for the presence of 11 AR genes by means of specific PCRs; species identification and genetic correlation among the isolates were determined, as well. It was concluded that this investigation provided evidences of the wide occurrence of AR genes in resistant staphylococci derived from various steps of the production chain of swine meat commodities. It emerged that both coagulase-positive and -negative resistant staphylococci carry a number of AR genes demonstrating the spread of multidrug resistance in bacteria of food origin too, and the importance of resistance surveillance in the food production environment.