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Prairie Swine Centre is an affiliate of the University of Saskatchewan
Prairie Swine Centre is grateful for the assistance of the George Morris Centre in developing the economics portion of Pork Insight.
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Compounding Iron Dextran with NSAIDs at Processing
Posted in: Pork Insight Articles, Prairie Swine Centre, Production by student on June 19, 2018
Author: Ron Johnson
Publication: Centred on Swine, Winter 2016 Volume 22 Number 2
Summary:
The objective of this project was to evaluate whether the mixing (compounding) of NSAIDs (anti-inflammatory/analgesic agents), such as meloxicam or flunixin meglumine, with iron dextran for administration to piglets at the time of processing has any effects on the availability of the NSAID.
In a series of experiments, the stability and systemic availability of both NSAIDs when mixed with iron dextran in the same bottle for administration to piglets at the time of processing was evaluated. Additionally, the effects of this practice on iron dextran’s ability to increase piglet hemoglobin concentrations were studied.
It was found that the amount of NSAID recovered from the bottle was reduced beginning shortly after mixing. As well that blood drug levels measured in piglets for each NSAID when compounded with iron dextran was significantly lower than when each NSAID was administered alone to piglets.
There were no significant effects of mixing NSAIDs with iron dextran on iron dextran’s ability to increase hemoglobin following administration to piglets. The overall conclusion from these experiments is that the mixing of NSAIDs with iron dextran in the same bottle for administration to piglets at the time of processing results in a suspected drug interaction that reduces the shelf-life of the formulation and the amount of NSAID available for therapeutic effects.
Compounding Iron Dextran with NSAIDs at Processing