Summary of research into using a plant model to produce an oral vaccine for Porcine reproductive and respiratory syndrome virus (PRRSV). The disease caused by PRRSV is a major source of economic loss for producers and current vaccines are not effective so development of an effective oral vaccine would be very beneficial to the swine industry. The researchers used the cholera toxin B subunit (CTB) of Vibrio cholerae as an adjuvant, PRRSV GP5 or its neutralizing epitope (GP5-NE) as a vaccine antigen and the tobacco plant as a plant model. Antigen expression in the tobacco plant was successful however of low yield so further research is needed to increase yeild of the viral protein. Legume plants were also studied as an easily administered form of the vaccine.