Improving the performance of nursery pigs immediately post-wean is important, but the effect on later hog performance of changing sow nutrients during gestation and lactation has been largely overlooked. Certain fatty acids and Selenium supplementation to lactating sow’s diet can help improve nursery performance during weaning. N-3 polyunsaturated fatty acids improve the piglet’s intestinal ability to transport glucose and glutamine, improving nutrient utilization and energy viability during weaning. Selenium is an antioxidant, so it helps reduce oxidation of tissues while the piglet is under stress, including the weaning period. Another way to improve nursery performance is to use plasma proteins to stimulate food intake while weaning; however, it has been difficult to implement. Now there is a product called Liquitein^TM, which allows plasma protein to be added to the water supply. It improves dry feed intake, rather than just promoting water intake. Finally, diet changes should be avoided during vaccination. By delaying the vaccination until after a diet change, stress is reduced and less weight loss occurs.