Water pollution from concentrated animal feeding operations (CAFOs) led to revised federal regulations in the United States. The regulations provide for the greater management of potential sources of agricultural contamination and impose additional financial costs on producers. Along with a duty to secure a permit, significant changes address coverage of pollutants, separation of production and land application areas, effluent limitation guidelines, and differentiating agricultural storm water discharges from other discharges. The revised provisions require more producers to secure National Pollutant Discharge Elimination System permits and mandate that large CAFOs develop technology-based effluent discharge limitations involving best management practices. Medium- and small-sized CAFOs need to adopt technology-based effluent discharge requirements employing best professional judgment. For farms raising animals that are not CAFOs, voluntary management practices may be employed to intercept pollutants before they enter waterbodies. Additional educational efforts promoting the implementation of further management practices that address the agricultural impairment of water resources may be needed.