Nutritional value of corn, wheat + corn (4:1) and wheat distiller’s grains with solubles (DDGS) for grower-finisher pigs was evaluated. Corn DDGS had the highest digestible energy (DE) and ileal digestible lysine contents but the digestible phosphorus (P) content was similar among DDGS samples. Following characterization of its digestible nutrient profile, DDGS still resulted in reductions in growth performance, suggestion that either the reduced average daily feed intake (ADFI) or other nutritional factors for DDGS deserve further investigation to ensure a successful implementation of DDGS in swine diets.