The cause of in-transit deaths in hogs is rarely examined, but a previous study identified that many of the hogs had heart lesions causing heart failure. When in-transit loss (ITL) hearts were compared to non-ITL hearts it was found ITL had a heavier average weight, visible enlargement was more common, and both groups had chronic, microscopic lesions in 76% of hearts. Genetic sequencing found 40 possible genes associated with the lesions, two of which are known to cause HCM in humans. Pig hearts are relatively small, so they have little ability to overcome challenges. Therefore, abnormalities can cause heart failure when heart rate is elevated. More extensive studies and genetic sequencing should be performed to determine how closely related pig heart lesions are related to hypertrophic cardiomyopathy (HCM) in other species.