In this research, we discuss the use of arsenicals in food-animal production and the evidence associating this use with increased levels of arsenic compounds in edible tissues. In addition to food consumption, the use of arsenicals in
animal feeds results in environmental pathways of exposure owing to waste-disposal practices common to intensive or industrial food-animal production. It was found that humans are exposed to arsenic via a number of environmental and dietary sources, all of which contribute to individuals’ cumulative arsenic burdens. Many of these sources, such
as naturally occurring arsenic in groundwater, are difficult or expensive to control, and as a result, challenges exist inmitigation of these exposures. Contrarily, as an intentional additive to poultry feed, the removal of arsenicals from the feed regimen is a cost-free intervention, mitigating not only exposures resulting from exposures
to waste-born arsenic, but also eliminating dietary exposures through consumption of contaminated animal products.