Data covering the fate and behavior of veterinary medicinal products (VMP) in manure and manure-applied soils has been significantly enhanced, thanks to recent research out of Germany. An innovative experimental design for laboratory tests on VMP was developed in order to simulate the real entry route of VMP into soil environments already under laboratory conditions. Degradation tests of VMP as 14C labeled radio-tracers in manures were conducted. Test manures containing seven-day aged VMP residues were prepared and then applied in laboratory batch tests to study degradation and absorption of VMP in soils containing manure. In further tests, the differentiation of microbial, chemical and photo-induced degradation were taken into account. Finally, test plot experiments were performed under field conditions to monitor the transferability of the laboratory data to field conditions. The degradation tests show the dependence of the metabolic fate on the microbial activity in the soil and on the test manure application. These aspects emphasize that the consideration of manure effects already under laboratory conditions support a better understanding of the environmental fate of VMP under field conditions.