African swine fever (ASF) a lethal, viral hemorrhagic disease of
\ndomestic pigs, first reported from East Africa in 1921, is still widespread in this
\nregion. In order to assess field heterogeneity at the regional level, nucleotide
\nsequences corresponding to the C-terminal end of the p72 gene were determined
\nfor 77 ASF viruses of diverse temporal and species origin occurring in eight
\nEast African countries. The number of sites completely conserved across all East
\nAfrican sequences characterized in this study was 84.2% and 86.8% on nucleotide
\nand amino acid level, respectively. Phylogenetic analysis of a homologous 404 bp
\nregion revealed the presence of thirteen East African genotypes, of which eight
\nappear to be country specific. An East African, pig-associated, homogeneous
\nvirus lineage linked to outbreaks in Mozambique, Zambia and Malawi over a 23
\nyear period was demonstrated. In addition, genotype I (ESACWA) viruses were
\nidentified in East African sylvatic hosts for the first time which is significant as this
\ngenotype was previously thought to be restricted to theWest African region where
\nit occurs only in domestic pigs. The presence of discrete epidemiological cycles
\nin East Africa and recovery of multiple genotypes affirms the epidemiological
\ncomplexity of ASF in this region.<\/p>\n","protected":false},"excerpt":{"rendered":"
African swine fever (ASF) a lethal, viral hemorrhagic disease of domestic pigs, first reported from East Africa in 1921, is still widespread in this region. In order to assess field heterogeneity at the regional level, nucleotide sequences corresponding to the C-terminal end of the p72 gene were determined for 77 ASF viruses of diverse temporal […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[930],"tags":[1809,5193,8882,13816,19216,8547,231,4023,19644,60,3804,20007,14804,111,3005,10985,10983,10995,5194,3465,14,33,16262,16371,5269,4467,35,20608,20911],"class_list":["post-3990","post","type-post","status-publish","format-standard","hentry","category-production","tag-acid","tag-african-swine-fever","tag-al","tag-ass","tag-assess","tag-complex","tag-cover","tag-cycle","tag-dd","tag-disease","tag-genetic","tag-gh","tag-hal","tag-health","tag-host","tag-lubisi-bastos-dwarca-molecular-epidemiology-of-african-swine-fever-in-east-africa","tag-lubisi-bastos-dwarka-molecular-epidemiology-of-african-swine-fever-in-east-africa","tag-lubisi-bastos-dwarka-vosloo-molecular-epidemiology-of-african-swine-fever","tag-molecular-epidemiology","tag-pea","tag-pig","tag-pigs","tag-pl","tag-puratone-ownership-structure","tag-report","tag-species","tag-swine","tag-swine-fever","tag-t"],"_links":{"self":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/3990","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/comments?post=3990"}],"version-history":[{"count":0,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/3990\/revisions"}],"wp:attachment":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/media?parent=3990"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/categories?post=3990"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/tags?post=3990"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}