Adiponectin is an adipocyte-derived
\nhormone that can improve insulin sensitivity. Its functions
\nin regulating glucose utilization and fatty acid
\nmetabolism in mammals are mediated by 2 subtypes
\nof adiponectin receptors (AdipoR1 and AdipoR2). This
\nstudy was conducted to determine the effect of fasting
\non the expression of adiponectin and its receptors.
\nThe expression of adiponectin was not affected in s.c.
\nadipose tissue, but adiponectin expression increased in
\nvisceral adipose tissue after fasting. In contrast, expression
\nof both AdipoR mRNA was increased in the liver
\nand s.c. adipose tissue of 24-h-fasted pigs compared
\nwith fed pigs, but the mRNA in muscle and visceral
\nadipose tissue was not affected by fasting. A third putative
\nadiponectin receptor, T-cadherin, was cloned and
\nthe mRNA expression was determined. T-Cadherin has
\nbeen recognized to act as a vascular adiponectin receptor
\nin vascular endothelial and smooth muscle cells. Our
\ndata showed that the expression of T-cadherin was decreased
\nin the muscle of fasted pigs, suggesting that the
\nexpression of T-cadherin can be regulated by feeding
\nstatus. In summary, in young pigs, adiponectin mRNA
\nwas up-regulated by fasting in visceral, but not s.c.,
\nadipose tissue, whereas AdipoR1 and AdipoR2 mRNA
\nwere increased in s.c., but not visceral, adipose tissue.
\nThe adiponectin receptor, T-cadherin, was expressed in
\ns.c. and visceral adipose tissue and in muscle, but only
\nmuscle mRNA expression was decreased by fasting.<\/p>\n","protected":false},"excerpt":{"rendered":"
Adiponectin is an adipocyte-derived hormone that can improve insulin sensitivity. Its functions in regulating glucose utilization and fatty acid metabolism in mammals are mediated by 2 subtypes of adiponectin receptors (AdipoR1 and AdipoR2). This study was conducted to determine the effect of fasting on the expression of adiponectin and its receptors. The expression of adiponectin […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[930],"tags":[1809,6780,6781,8882,22809,2851,6904,46,108,651,517,14,33,20911,6782],"class_list":["post-4070","post","type-post","status-publish","format-standard","hentry","category-production","tag-acid","tag-adiponectin","tag-adiponectin-receptor","tag-al","tag-fast","tag-fat","tag-fee","tag-feed","tag-feeding","tag-growing-pig","tag-growing-pigs","tag-pig","tag-pigs","tag-t","tag-t-cadherin"],"_links":{"self":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/4070","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/comments?post=4070"}],"version-history":[{"count":0,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/4070\/revisions"}],"wp:attachment":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/media?parent=4070"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/categories?post=4070"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/tags?post=4070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}