{"id":4115,"date":"2007-01-01T01:01:01","date_gmt":"2007-01-01T01:01:01","guid":{"rendered":"http:\/\/export.maxmaziy.php.nixsolutions.com\/?p=4115"},"modified":"2007-01-01T01:01:01","modified_gmt":"2007-01-01T01:01:01","slug":"structural-analysis-and-haplotype-diversity-in-swine-lep-and-mc4r-genes","status":"publish","type":"post","link":"http:\/\/prairieswine.com\/rsc\/structural-analysis-and-haplotype-diversity-in-swine-lep-and-mc4r-genes\/","title":{"rendered":"Structural analysis and haplotype diversity in swine LEP and MC4R genes"},"content":{"rendered":"<p>Knowledge about structural variation of candidate genes could be<br \/>\nimportant to improve breeding selection scheme and preserve genetic<br \/>\nvariability in livestock species. Leptin (LEP) and melanocortin-4 receptor<br \/>\n(MC4R) genes are involved in the energetic pathway and are obvious<br \/>\ncandidate genes for fatness. By sequencing LEP and MC4R genes in 72<br \/>\npigs belonging to lean (Large White and Duroc), fat (Meishan and<br \/>\nCasertana) breeds and also Wild Boar, 98 polymorphic sites, of which<br \/>\n91 were novel, were found in the Leptin sequence while only the previously<br \/>\ndescribed mutation was found in the MC4R gene. A total of 18<br \/>\nLEP haplotypes were observed and their distribution was unequal<br \/>\namong the breeds. The phylogenetic analysis showed two haplotype<br \/>\nbranches distinguishing between lean and fat breeds.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Knowledge about structural variation of candidate genes could be important to improve breeding selection scheme and preserve genetic variability in livestock species. Leptin (LEP) and melanocortin-4 receptor (MC4R) genes are involved in the energetic pathway and are obvious candidate genes for fatness. By sequencing LEP and MC4R genes in 72 pigs belonging to lean (Large [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[930],"tags":[8882,5162,2349,2344,7807,9112,6250,2559,2851,3804,9230,14784,14,33,16262,4467,12694,35,20911,4874,18011,2446,1055,15479],"class_list":["post-4115","post","type-post","status-publish","format-standard","hentry","category-production","tag-al","tag-boar","tag-breed","tag-breeding","tag-breeds","tag-casertana-pig","tag-casertana-pig-breed-haplotypes-leptin-melanocortin-4-receptor","tag-duroc","tag-fat","tag-genetic","tag-meishan","tag-ness","tag-pig","tag-pigs","tag-pl","tag-species","tag-structural-analysis-and-haplotype","tag-swine","tag-t","tag-tan","tag-tot","tag-variability","tag-variation","tag-wild"],"_links":{"self":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/4115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/comments?post=4115"}],"version-history":[{"count":0,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/4115\/revisions"}],"wp:attachment":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/media?parent=4115"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/categories?post=4115"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/tags?post=4115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}