{"id":4469,"date":"2009-01-01T01:01:01","date_gmt":"2009-01-01T01:01:01","guid":{"rendered":"http:\/\/export.maxmaziy.php.nixsolutions.com\/?p=4469"},"modified":"2011-12-06T11:25:01","modified_gmt":"2011-12-06T17:25:01","slug":"duration-of-feeding-linseed-diet-influences-expression-of-inflammation-related-genes-and-growth-performance-of-growing-finishing-barrows","status":"publish","type":"post","link":"http:\/\/prairieswine.com\/rsc\/duration-of-feeding-linseed-diet-influences-expression-of-inflammation-related-genes-and-growth-performance-of-growing-finishing-barrows\/","title":{"rendered":"Duration of feeding linseed diet influences expression of inflammation-related genes and growth performance of growing-finishing barrows"},"content":{"rendered":"<p>The aim of the study was to investigate the effects of dietary linseed (rich in n-3 PUFA) on expression of inflammation-related genes and on growth performance of growing-finishing barrows. Two isoenergetic and isonitrogenous diets were formulated, one as the basal diet and the other containing 10% linseed. Twenty-four Landrace \u0081~ Yorkshire barrows weighing 35 \u0081} 3.7 kg were randomly assigned to 1 of 4 treatment groups, with 6 pigs per group. During the entire experimental period of 90 d, these 4 groups of pigs were first fed the basal diet and then fed the linseed diet for 0, 30,<br \/>\n60, and 90 d before slaughter, respectively. Pig growth; messenger RNA (mRNA) expression of peroxisome proliferator-activated receptor-\u0192\u00c1 (PPAR\u0192\u00c1), IL-1\u0192\u00c00, IL- 6, and tumor necrosis factor-\u0192\u00bf (TNF-\u0192\u00bf); and plasma concentrations of the 3 proinflammatory cytokines were measured and analyzed. Average daily feed intake did not differ among treatment groups (P &gt; 0.05), but ADG (P &lt; 0.05) and G:F (P &lt; 0.01) responded quadratically to the duration of linseed diet feeding, and pigs in the 60-d treatment group had the greatest ADG and G:F. The mRNA expression of PPAR\u0192\u00c1 in loin muscle<br \/>\nand spleen increased linearly (P &lt; 0.01) with the duration of linseed diet feeding, whereas its expression in adipose tissue was not affected (P = 0.095). Tumor necrosis factor-\u0192\u00bf and IL-6 mRNA expression in muscle, adipose, and spleen, as well as serum concentration of TNF-\u0192\u00bf, decreased linearly (P &lt; 0.01) with the duration of linseed diet feeding. Peroxisome proliferator-activated receptor-\u0192\u00c1 mRNA abundance was negatively correlated with IL-1\u0192\u00c0, IL-6, and TNF-\u0192\u00bf mRNA abundance both in muscle (R2 = 0.63, P &lt; 0.001) and in spleen (R2 = 0.69, P &lt; 0.001), and PPAR\u0192\u00c1 mRNA expression in spleen (R2 = 0.59, P &lt; 0.01) and muscle (R2 = 0.52, P &lt; 0.05) was negatively correlated with serum TNF-\u0192\u00bf concentration. There were also significant quadratic relations between ADG and expression of PPAR\u0192\u00c1 (P &lt;<br \/>\n0.05) and splenic TNF-\u0192\u00bf (P &lt; 0.05). These data suggest that intake of n-3 PUFA from the linseed diet led to significant decreases in the expression of proinflammatory cytokine genes, which may stimulate growth in growing-finishing barrows, at least in part, through a PPAR\u0192\u00c1-dependent mechanism.<\/p>\n<p>&nbsp;<\/p>\n<p>For more information the full article can be found at <a href=\"http:\/\/jas.fass.org\/\">http:\/\/jas.fass.org\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The aim of the study was to investigate the effects of dietary linseed (rich in n-3 PUFA) on expression of inflammation-related genes and on growth performance of growing-finishing barrows. Two isoenergetic and isonitrogenous diets were formulated, one as the basal diet and the other containing 10% linseed. Twenty-four Landrace \u0081~ Yorkshire barrows weighing 35 \u0081} [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[930],"tags":[13816,1464,7321,577,1287,6904,46,925,108,124,20007,158,20792,7099,9846,6977,15920,26125,6986,187,63,7289,14,33,16262,92,7290,76,26100,20912,20911,1579,26223,52,6853,4176],"class_list":["post-4469","post","type-post","status-publish","format-standard","hentry","category-production","tag-ass","tag-average-daily-feed-intake","tag-barrows","tag-diet","tag-diets","tag-fee","tag-feed","tag-feed-intake","tag-feeding","tag-finishing","tag-gh","tag-growth","tag-influence","tag-landrace","tag-lee","tag-linseed","tag-loin-muscle","tag-meat-slaughtering-procedures-ppt","tag-n-3-polyunsaturated-fatty-acid","tag-nitrogen","tag-performance","tag-peroxisome-proliferator-activated-receptor-a","tag-pig","tag-pigs","tag-pl","tag-plasma","tag-proinflammatory-cytokine","tag-slaughter","tag-soe","tag-some","tag-t","tag-test","tag-the-effects","tag-treatment","tag-weighing","tag-yorkshire"],"_links":{"self":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/4469","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/comments?post=4469"}],"version-history":[{"count":3,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/4469\/revisions"}],"predecessor-version":[{"id":10938,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/4469\/revisions\/10938"}],"wp:attachment":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/media?parent=4469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/categories?post=4469"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/tags?post=4469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}