Porcine circovirus type 2 (PCV2) infection of natural interferon producing
\ncells (NIPCs) impairs the induction of interferon (IFN)-a and
\ntumour necrosis factor (TNF)-a by cytosine-phosphorothioate-guanine
\n(CpG) oligodeoxynucleotides (ODNs), thereby preventing both their autocrine
\nmaturation and the paracrine maturation of myeloid dendritic cells
\n(DCs). The present study shows that the PCV2-mediated inhibition of
\nNIPCs was mediated by viral DNA, although it was independent of virus
\nreplication. The inhibitory effect of PCV2 DNA was more diversified than
\nif it had simply targeted CpG-ODN-induced cytokines (IFN-a, TNF-a,
\ninterleukin-6, IL-12). A broad spectrum inhibition was noted, affecting
\nresponses induced by toll-like receptor (TLR)-7 and TLR9 agonists, as
\nwell as viruses including pseudorabies virus, transmissible gastroenteritis
\nvirus and classical swine fever virus. From these results, it would appear
\nthat PCV2 DNA can induce a dominant negative signal influencing independent
\npattern recognition receptor-induced activation cascades. Despite
\na concomitant internalization of PCV2 DNA and CpG-ODNs, no colocalization
\nwas observed, indicating that PCV2 DNA and CPG-ODNs may not
\ntarget the same receptor. This study describes a novel modulation of the
\ninnate immune response, which would render the host more susceptible
\nto secondary or concomitant microbial infections.<\/p>\n","protected":false},"excerpt":{"rendered":"
Porcine circovirus type 2 (PCV2) infection of natural interferon producing cells (NIPCs) impairs the induction of interferon (IFN)-a and tumour necrosis factor (TNF)-a by cytosine-phosphorothioate-guanine (CpG) oligodeoxynucleotides (ODNs), thereby preventing both their autocrine maturation and the paracrine maturation of myeloid dendritic cells (DCs). The present study shows that the PCV2-mediated inhibition of NIPCs was mediated […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[928],"tags":[8882,13816,2817,24566,3734,316,20007,3005,6577,3794,26380,853,10859,5310,10766,15486,7816,3465,16262,19940,6230,17743,35,20608,20911,4874],"class_list":["post-5476","post","type-post","status-publish","format-standard","hentry","category-welfare","tag-al","tag-ass","tag-cla","tag-cv2","tag-dna","tag-gas","tag-gh","tag-host","tag-immune","tag-immune-response","tag-infec","tag-inhibition","tag-nat","tag-natural-interferon-producing-cells-dna-porcine-circovirus-type-2-inhibition-toll-like-receptors","tag-nucleotides","tag-pcs","tag-pcv","tag-pea","tag-pl","tag-porc","tag-porcine-circovirus","tag-prod","tag-swine","tag-swine-fever","tag-t","tag-tan"],"_links":{"self":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/5476","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/comments?post=5476"}],"version-history":[{"count":0,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/5476\/revisions"}],"wp:attachment":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/media?parent=5476"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/categories?post=5476"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/tags?post=5476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}