{"id":8663,"date":"2011-08-12T13:44:00","date_gmt":"2011-08-12T13:44:00","guid":{"rendered":"http:\/\/prairieswine.com\/rsc\/?p=8663"},"modified":"2011-11-25T17:32:09","modified_gmt":"2011-11-25T17:32:09","slug":"oral-administration-of-saccharomyces-cerevisiae-boulardii-reduces-mortality-associated-with-immune-and-cortisol-responses-to-escherichia-coli-endotoxin-in-pigs","status":"publish","type":"post","link":"http:\/\/prairieswine.com\/rsc\/oral-administration-of-saccharomyces-cerevisiae-boulardii-reduces-mortality-associated-with-immune-and-cortisol-responses-to-escherichia-coli-endotoxin-in-pigs\/","title":{"rendered":"Oral administration of Saccharomyces cerevisiae boulardii reduces mortality associated with immune and cortisol responses to Escherichia coli endotoxin in pigs"},"content":{"rendered":"

The effects of active dry yeast, <\/span>Saccharomyces cerevisiae boulardii <\/span><\/em>(<\/span>Scb<\/span><\/em>), on the immune\/cortisol response and subsequent mortality to <\/span>Escherichia coli <\/span><\/em>lipopolysaccharide (LPS) administration were evaluated in newly weaned piglets (26.1 d of age). Barrows were assigned to 1 of 2 treatment groups: with (<\/span>Scb<\/span><\/em>; n = 15) and without (control; n = 15) the in-feed inclusion of <\/span>Scb <\/span><\/em>(200 g\/t) for 16 d. On d 16, all piglets were dosed via indwelling jugular catheters with LPS (25 \u03bcg\/kg of BW) at 0 h. Serial blood samples were collected at 30-min intervals from \u22121 to 6 h and then at 24 h. Differential blood cell populations were enumerated hourly from 0 to 6 h and at 24 h. Serum cortisol, IL-1\u03b2, IL-6, tumor necrosis factor-\u03b1 (TNF-\u03b1), and interferon-\u03b3 (IFN-\u03b3) concentrations were determined via porcine-specific ELISA at all time points. In <\/span>Scb<\/span><\/em>-treated piglets, cumulative ADG increased by 39.9% and LPS-induced piglet mortality was reduced 20% compared with control piglets. White blood cells, lymphocytes, and neutrophils were increased in <\/span>Scb<\/span><\/em>-treated animals before LPS dosing compared with control piglets before being equally suppressed from baseline in both treatments after LPS dosing with a return to baseline by 24 h. Suppression of circulating cortisol concentrations was observed in <\/span>Scb<\/span><\/em>-treated piglets from \u22121 h to 1 h relative to LPS dosing compared with control animals before both peaked equally and subsequently returned to baseline. Peak production of IL-1\u03b2 and IL-6 was less in <\/span>Scb<\/span><\/em>-treated piglets after LPS administration compared with controls before both equally returned to baseline. Peak TNF-\u03b1 production in <\/span>Scb<\/span><\/em>-treated animals was accelerated 0.5 h and was greater than peak production in control piglets, after which both equally returned to baseline. The peak production of IFN-\u03b3 was greater and had increased amplitude persistence for 3 h in <\/span>Scb<\/span><\/em>-treated animals compared with control piglets before both equally returned to baseline. These results highlight the previously unidentified effects of <\/span>Scb <\/span><\/em>administration on immune and cortisol responses and the subsequent impact on growth and endotoxin induced mortality in weaned piglets.<\/span><\/span><\/span><\/p>\n

\u00a0<\/p>\n

For more information the full article can be found at http:\/\/jas.fass.org\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The effects of active dry yeast, Saccharomyces cerevisiae boulardii (Scb), on the immune\/cortisol response and subsequent mortality to Escherichia coli lipopolysaccharide (LPS) administration were evaluated in newly weaned piglets (26.1 d of age). Barrows were assigned to 1 of 2 treatment groups: with (Scb; n = 15) and without (control; n = 15) the in-feed […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[930],"tags":[8882,640,13816,7321,2817,22399,2558,6802,6904,46,20007,158,6577,5381,6848,606,10143,21335,3465,14,126,7160,89,33,16262,19940,17743,27282,14805,10755,10152,8277,1533,20911,26223,52,3790,6244,15383,3325,10764],"class_list":["post-8663","post","type-post","status-publish","format-standard","hentry","category-production","tag-al","tag-animal","tag-ass","tag-barrows","tag-cla","tag-coli","tag-cortisol","tag-cytokine","tag-fee","tag-feed","tag-gh","tag-growth","tag-immune","tag-light","tag-lipopolysaccharide","tag-mortality","tag-oral-administration-of-saccharomyces-cerevisiae-boulardii-reduces-mortality","tag-oral-endotoxin-swine","tag-pea","tag-pig","tag-piglet","tag-piglet-mortality","tag-piglets","tag-pigs","tag-pl","tag-porc","tag-prod","tag-production","tag-rn","tag-saccharomyces","tag-saccharomyces-cerevisiae-and-cortisol","tag-saccharomyces-cerevisiae-boulardii","tag-size","tag-t","tag-the-effects","tag-treatment","tag-weaned","tag-weaned-pig","tag-weaned-piglet","tag-weaned-piglets","tag-yeast"],"_links":{"self":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/8663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/comments?post=8663"}],"version-history":[{"count":5,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/8663\/revisions"}],"predecessor-version":[{"id":10376,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/posts\/8663\/revisions\/10376"}],"wp:attachment":[{"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/media?parent=8663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/categories?post=8663"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/prairieswine.com\/rsc\/wp-json\/wp\/v2\/tags?post=8663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}