Feed makes up the majority of producer costs, and as knowledge of nutritional content increases it is important to utilize it to increase productivity. The Canadian Swine Research and Development Cluster program is researching the effect of diet on post-weaning to market performance, the variable nutritional content of byproducts such as corn DDGS, and the development of software to utilize nutritional information. Post-weaning pig performance was evaluated with simple or complex diets, and the addition of antibiotics (chlortetracycline). Preliminary results show the performance for those fed with complex or additional antobiotics was increased for the first six weeks post-weaning, but did not impact long-term growth rates and performance. Feed costs can be lowered with the addition of byproducts such as corn DDGS, the problem is the nutritional value is often highly variable. A large scale sampling is ongoing to test nutrient value through nutritional analysis, colour, near-infrared sceptroscopy, in vivo and in vitro nutritional and availability assays. Fibre-degrading enzymes and microbial inoculants were shown to increase the nutritional availability for corn DDGS, and was the most effective in a liquid diet. Finally, software is being designed to integrate nutritional knowledge into one program, and allow predictions for nutritional requirements for populations including GnRF immunized intact boars. Accurate assessment of nutritional content and requirements will allow economic savings, and steady performance for producers.