Neonatal piglet diarrhea is a significant cause of pre-weaning mortality, and has multiple diseases which can cause it. The relative contribution of different diseases has been changing as management, sanitation, and disease strains shift. Neonatal diarrhea occurs most frequently in the winter, and some of the pathogens which cause it include enterotoxigenic E. coli (ETEC), Clostridium perfringens, Clostridium difficile, rotavirus, and Cystisospora suis. 237 piglets with gastrointestinal tract issues were sampled between 2001-2010. 33% had no identifiable pathogen associated with it, but the other 66% showed at least one pathogen. ETEC was found in 31% of total cases, C. perfringens was in 12%, Rotovirus in 12%, C. difficile in 9%, and Cystisospora suis was diagnosed in 6% of cases. Interactions were found between pathogens, and often more than one was present.