Preparing the barn should start with clearing of organic matter with water, and then a detergent or degreaser should be applied to remove biofilms. Biofilms can be organic or mineral: an acidic detergent will remove mineral biofilms and alkaline detergents will remove organic biofilms. An alkaline and acidic detergent can be alternated to remove both over two rotations. Next, the room should be allowed to completely dry and a disinfectant applied. If the disinfectant is potentially toxic the room may need to be rinsed before animals are moved in. The room should be allowed to completely dry before moving animals in, which can be aided by the use of ventilation or heat.