Dead and non-ambulatory pigs account for only 0.69% of shipped pigs, but this still result in $46 million profit loss per year. There is no national data on non-ambulatory pigs, so only commercial field trial data can be used. This data shows that the majority of non-ambulatory pigs are fatigued rather than injured. Seasonal variation results in more dead pigs during transport in summer months, and more non-ambulatory pigs during fall and early winter. Some of the management strategies to reduce dead and non-ambulatory pigs during transport can be through changes in preparing the pigs for transport, facility design, handling, and transport conditions. For preparing the pigs, ways to reduce stress include previously handling pigs and withdrawing feed around 24 hours beforehand. The facility can be improved by decreasing loading distance, having large pens with pre-sorting capabilities, and changing the ramp design (angle). To minimize stress during handling, pigs should be moved primarily with boards, the use of electric prods should be minimized, groups should be kept small, and the intensity of handling should be reduced to give pigs time and space to move. Ways to optimize the trailer design are to use a straight-deck, provide more space per pig, avoid mixing unfamiliar pigs, and have strategies to reduce the impact of hot and cold weather. Many of these strategies require more studies on larger groups of pigs to confirm the results. Reducing the stress during transportation can help lower death and non-ambulatory rates during transport, and reduce the economic loss from these pigs.