Improving nursery and grow-finish performance can help to increase profitability. PRRS is an expensive virus in terms of its effect on performance, so every effort should be made to keep it out of the nursery where pigs are vulnerable to disease challenges. Ways to manage nursery PRRS are to eradicate it in the sow herd if possible, or to increase the age of infection for nursery pigs. Nursery pigs should be given sufficient space, and kept in an environment at the optimal temperature. Good stockmanship in the nursery includes proper sanitation, adjusting temperature, feeders, and drinkers, and intervening if pigs are not eating 36 hours post-weaning. The nursery should have a feed budget that switches pigs to simpler diets as soon as possible. The feed budget’s effectiveness can be maintained by proper room management, increasing the age of weaning, and measuring weights as much as possible. The health status should be kept high through controlling other pathogen levels by vaccinating, medication, or depopulating and repopulating. The grow-finish room should be clean and set-up before the nursery pigs are transferred over. Grow-finishers often are affected by respiratory diseases around week 20, so vaccinations, ventilation and density management can be used to help prevent this. The finishing feed diets should be budgeted to avoid wasted costs and feed wastage. Chores like barn walk-throughs and individual pig treatments can help fix problems before they become serious. Finally, grower diarrhea incidences should be controlled through medication, sanitation, and biosecurity.