Vaccination of livestock is crucial to developing specific immune resistance to diseases that otherwise cost producers billions of dollars. Vaccination of livestock with needles, intramuscular and subcutaneous, can incur costs through animal stress, vaccine residues, injection site lesions and broken needles. Needle-free injection offers several benefits over traditional means. Vaccine is dispersed as minute particles in skin and other tissue, greatly increasing exposure to white blood cells, and thus improving vaccine uptake. Entry points are minute, minimizing tissue damage at the injection site. The injector can be loaded for multiple injections and needle stick injuries are eliminated. This study, carried out at the University of Saskatchewan.s Vaccine & Infectious Disease Organization (VIDO), evaluated commercial vaccine delivery to piglets using a low-pressure, needle-free jet injector against intra-muscular delivery and found that resulting immunity in needle-free animals was as good or better than that developed by animals immunized using a syringe and needle. Animals immunized with the needle-free jet injector also experienced milder clinical disease. This work confirmed similar results achieved by researchers using other drugs or vaccines. The amount of vaccine remaining on the skin surface post-vaccination with the needle-free method suggested that further studies of needle-free injections could lead to establishment of much smaller effective vaccination doses with this system.