Diseases in the nursery are likely to persist due to diseases evolving, poor practices, or biosecurity breaches. Disease development cannot be controlled, so instead good management and production practices should be focused on. One of the prevention practices is to minimize the number of sources of nursery pigs. Another consideration is where the nursery is located in relation to other swine barns, with hog dense areas needing stricter biosecurity. Herd stability and high passive immunity, strict all-in all-out nursery and farrowing pig flow, and avoiding coinfections influence nursery disease prevalence. Finally, a good human resource team, management, and developing SOPs for other employees will help keep all aspects of the barn running well, including nursery health.