When a new disease enters the herd there are indirect costs from increased mortality and decreased performance, and direct costs from treatment or vaccines. The effectiveness of a treatment or vaccine should be considered, and certain ones can bring additional risks as well. If things are not improving, the barn should be examined by someone outside (veterinarian, feed representative etc.), advisors and spreadsheets should be used to see costs and make decisions, and the producer should set an expense point that will not be crossed.