Enterotoxigenic Escherichia coli is a major problem in the swine industry and results in scouring, increased mortality, and poor performance in the period immediately postweaning. The traditional way to control this problem is to include subtherapeutic antibiotics in the feed, but this is no longer acceptable to consumers; thus, alternatives to antibiotics are needed. In this research, we investigated the effects of spray-dried porcine plasma(SDPP), a Bacillus subtilis direct-fed microbial (DFM), a blend of organic acids, and sweeteners on E. coli induced scouring. It was concluded that when SDPP and DFM were included in the diet, the incidence of Bacteroidetes was greater when there was no antibiotics in the diet.