The objective of this study was to investigate the impact of disease on the Proftit margin (PM) using data from individual boars at a Danish boar test station. Treatments were used as indicators of disease in the finishing period and, records of pathological lesions were used as an indicator of disease at slaughter. The objective was studied by means of a multivariable hierarchical analysis. The explanatory variables comprised breed and weight at 4 weeks. It was found that disease had a significant negative effect on the PM in individual boars reaching a slaughter weight of at least 80 kg. Parenteral treatment was associated with a larger reduction in the PM than oral treatment. Also pathological findings at slaughter were associated with a negative effect on the PM. The effect of pathological
findings was influenced by breed. The results were shown to be robust to changes in the price of a 30 kg piglet and relatively robust in regard to the price of feed. However, price of kg carcass weight and medicine appeared to influence the analysis results.