Increased utilization of biofuel coproducts, such as crude glycerol, will allow livestock producers to source alternative feedstuffs and mitigate high grain prices. Crude glycerol may play an important role in meeting the dietary energy needs of pigs as biodiesel production expands. The present study indicates that crude glycerol can be included up to 8% in replacement for wheat in diets for weaned pigs, without reducing growth and feed efficiency.